Usually, if you are experiencing Canon printer error E16 then it means that the ink cartridge is out of ink and you need to refill it again. If you try printing a document and are unable to do it then it means that the ink in the cartridge needs to be refilled. If you do not refill the cartridge and continue to run it on low ink then it can permanently damage the ink cartridges.
If you are having a hard time resolving the Canon Printer Error E16 on your printer then you can follow the troubleshooting guidelines mentioned in this blog. However, if you need an immediate response to fixing the problem then getting help from the Canon technicians is the best solution.